Which NSAID is often preferred for cardiovascular risk considerations?

Which NSAID is often preferred for cardiovascular risk considerations?

• A. Ibuprofen
• B. Ketoprofen
• C. Naproxen
• D. Diclofenac

Answer: (C)

When evaluating cardiovascular safety with NSAIDs, the aim is to choose the option that carries the least risk of heart-related events while still relieving pain. Naproxen has the most favorable cardiovascular safety profile among common NSAIDs; evidence consistently shows higher risks with diclofenac and with ibuprofen at typical or higher doses, whereas naproxen’s risk is comparatively lower. This is why it’s often the preferred choice when cardiovascular risk is a concern. Keep in mind that NSAIDs can interact with aspirin’s cardioprotective effect, so timing and use in patients taking low-dose aspirin should be considered. Data on ketoprofen are less robust, reinforcing naproxen as a safer default for CV risk considerations.

When evaluating cardiovascular safety with NSAIDs, the aim is to choose the option that carries the least risk of heart-related events while still relieving pain. Naproxen has the most favorable cardiovascular safety profile among common NSAIDs; evidence consistently shows higher risks with diclofenac and with ibuprofen at typical or higher doses, whereas naproxen’s risk is comparatively lower. This is why it’s often the preferred choice when cardiovascular risk is a concern. Keep in mind that NSAIDs can interact with aspirin’s cardioprotective effect, so timing and use in patients taking low-dose aspirin should be considered. Data on ketoprofen are less robust, reinforcing naproxen as a safer default for CV risk considerations.