Partial androgen insensitivity is typically associated with which phenotype?

Partial androgen insensitivity is typically associated with which phenotype?

• A. Phenotypically male
• B. Phenotypically female
• C. Ambiguous
• D. Normal male

Answer: (A)

Partial androgen insensitivity means the androgen receptor works only partially, so some androgen signaling occurs but not fully. With an XY genotype, testes produce testosterone, and because some signaling remains, external genital development is typically male, though undervirilized (for example, hypospadias or micropenis can be present). This makes the most common presentation phenotypically male. In contrast, complete androgen insensitivity leads to a phenotypically female appearance, which is why this question emphasizes the partial form as male-appearing overall.

Partial androgen insensitivity means the androgen receptor works only partially, so some androgen signaling occurs but not fully. With an XY genotype, testes produce testosterone, and because some signaling remains, external genital development is typically male, though undervirilized (for example, hypospadias or micropenis can be present). This makes the most common presentation phenotypically male. In contrast, complete androgen insensitivity leads to a phenotypically female appearance, which is why this question emphasizes the partial form as male-appearing overall.